Tag: medical research

Japanese Study: Caffeic Acid in Coffee Inhibits Colorectal Cancer Cell

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GrowthKyoto – Qahwa World

A Japanese research team has identified the molecular mechanism by which caffeic acid, a polyphenol found in coffee, suppresses the growth of colorectal cancer (CRC) cells.

This discovery, published in Scientific Reports on March 5, 2026, provides a potential scientific basis for epidemiological studies that link regular coffee consumption to a reduced risk of colorectal cancer.

The Molecular Mechanism: Targeting the RPS5-Cyclin D1 Axis While previous research suggested a link between coffee and cancer prevention, the specific components and their biological functions remained unclear.

You may read: Japanese Scientists: Coffee Protects Gums from Inflammation

Researchers from Kyoto Prefectural University of Medicine and Kansai Medical University Hospital focused on caffeic acid, which is produced when chlorogenic acid (abundant in coffee) is hydrolyzed in the intestines.

Key findings from the study include: Direct Binding to RPS5: Using nano-magnetic beads and mass spectrometry, the team identified ribosomal protein S5 (RPS5) as a direct binding target of caffeic acid. High expression of RPS5 is known to be associated with poor prognosis in colorectal cancer patients.

Inducing G1 Cell Cycle Arrest: The research demonstrated that caffeic acid blocks the function of RPS5, which in turn halts the cell cycle of cancer cells at the G1 phase, preventing them from copying their DNA and proliferating.

You may also read: Why Coffee Is One of the Healthiest Drinks

Post-Transcriptional Regulation of Cyclin D1: Both the addition of caffeic acid and the suppression of RPS5 reduced the levels of cyclin D1, a protein critical for driving the cell growth cycle. The study suggests that RPS5 regulates cyclin D1 by controlling the stability of its messenger RNA (mRNA) rather than its promoter activity.

Future Therapeutic Potential Dr. Motoki Watanabe, the lead researcher, stated that these findings reveal a previously unrecognized RPS5-cyclin D1 axis targeted by caffeic acid. This insight could lead to the development of new cancer prevention strategies and treatments, such as optimized derivatives of caffeic acid that more effectively target RPS5.

Important Considerations The researchers noted that this was basic research conducted primarily on cell cultures. They cautioned that the concentrations of caffeic acid required for these effects in a laboratory setting are higher than what is typically achieved through normal coffee consumption. Additionally, since coffee contains other components like caffeine and may not suit everyone’s constitution, excessive consumption is not recommended.

Shocking Discovery: Just One Cup of Coffee May Reduce Donor Blood Quality

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Dubai, September 8, 2025 (Qahwa World) – A groundbreaking study published in Haematologica has revealed that caffeine, the world’s most widely consumed stimulant, can significantly reduce the quality of stored donor blood, potentially limiting the benefits of transfusions for patients.

The research, based on data from more than 13,000 blood donors, examined caffeine levels and their impact on red blood cell function during storage. The results showed that blood taken from donors with high caffeine exposure was more fragile and less effective after transfusion. The cells demonstrated depleted energy reserves such as adenosine triphosphate, reduced levels of 2,3-bisphosphoglycerate, and increased oxidative stress markers, making them more prone to breakdown.

The study further revealed that not all donors were affected equally. Negative effects were especially pronounced among individuals carrying variants of the ADORA2b gene, which regulates how red blood cells adapt to low oxygen. When caffeine blocks this receptor, stored blood deteriorates faster, resulting in weaker clinical outcomes for transfusion recipients.

Laboratory experiments confirmed that caffeine’s harm operates on two fronts: first, by blocking ADORA2b signaling, and second, by directly inhibiting glucose-6-phosphate dehydrogenase, a key enzyme responsible for red cell antioxidant defenses. This dual mechanism leaves cells more vulnerable to oxidative stress and shortens their survival after transfusion.

The health implications are significant. With more than twelve million units of blood transfused annually in the United States alone, even small reductions in blood quality can have widespread consequences. Encouragingly, caffeine is a modifiable factor. Because of its short biological half-life, abstaining from coffee or caffeinated drinks for even a single day before donation may improve blood quality. Some European countries already advise donors to avoid caffeine, while in the United States and Italy it is sometimes encouraged to help raise blood pressure temporarily, easing the donation process.

Researchers, led by Professor Angelo D’Alessandro of the University of Colorado, emphasize that these findings highlight the need for a more personalized approach to transfusion medicine. In addition to blood type, factors such as lifestyle and genetic background should be considered to ensure the highest quality units are directed to patients most at risk, such as infants or individuals with severe anemia.

The paradox is striking: the same mechanisms that make caffeine harmful for stored blood may explain its appeal to athletes. A modest increase in oxidative stress can stimulate adaptation in the body, improving endurance. But inside blood banks, this effect translates into weaker units and reduced potential to save lives.